2019 Volume 61 Issue 2 Pages 156-162
Case 1 was a 51-year-old man who was referred to our hospital by a local clinic because he had amebic colitis that was resistant to treatment with metronidazole (MNZ). Case 2 was a 53-year-old man who was diagnosed with amebic colitis at our hospital. Both patients received 2 courses of MNZ treatment, but in both patients, ulcers remained in the large intestine on colonoscopy. Following treatment with MNZ, paromomycin (PRM) was orally administered and healing was confirmed by colonoscopy. Residual cysts were considered to be responsible for the resistance to treatment with MNZ in both cases. Based on previous reports and our experiences, we perform colonoscopy 2 to 3 months after completion of MNZ treatment in patients with amebic colitis, and diagnose the patient as having resistance to treatment with MNZ if ulcers remain. It seems better to treat amebic colitis with MNZ and PRM in combination.
