ENDOSCOPIC ULTRASONOGRAPHY-GUIDED CELIAC PLEXUS NEUROLYSIS

Abstract

Endoscopic ultrasonography-guided celiac plexus neurolysis (EUS-CPN) is performed to alleviate upper abdominal pain. The response rate has been reported to be 46％−81％, and this procedure has made it possible to reduce the opioid dose. In two randomized controlled studies, the efficacy of EUS-CPN that was performed at an early pain stage was evaluated; the results of these two studies have been discordant since its efficacy appears to be limited when appropriate medications are combined. Given the possible severe adverse events and negative effects on prognosis, EUS-CPN should be performed for reasons such as severe pain that cannot be controlled using drugs, intolerance to opioids, hindrance towards frequent hospital visits, and financial problems.