2021 Volume 63 Issue 9 Pages 1603-1608
The patient was a 32-year-old woman who presented diarrhea, bloody stool, and 38-degree fever during treatment for SAPHO syndrome using salazosulfapyridine enteric coated tablets (1,000mg). We performed colonoscopy. Although the case was atypical, we suspected ulcerative colitis due to the presence of continuous lesions from the descending colon to the cecum, and changed to time-dependent release mesalazine (2,000mg) and mesalazine enema (1g). She then presented shivering, a 39-degree fever, headache, and arthralgia. The drug was discontinued in consideration of the side effects of mesalazine. The patient’s fever improved 24 hours later. The drug was subsequently discontinued because the patient’s side effects recurred with re-administration, and the patient was diagnosed with 5-ASA intolerance. Since mucosal healing was confirmed by colonoscopy approximately 1 month later, we diagnosed the patient with drug-induced enteritis due to salazosulfapyridine and considered that the causative component was 5-ASA.
