EUS-GUIDED TISSUE ACQUISITION FOR GENOMIC PROFILING OF BILIARY TRACT CANCER

Abstract

With the development of next-generation sequencing, Japanese health insurance has covered comprehensive genomic profiling (CGP) using tumor tissue samples and liquid biopsy. We have them available in clinical practice. We have to consider CGP for precision medicine. For CGP using tumor tissue samples, more good quality tissue samples are necessary. EUS-guided tissue acquisition (EUS-TA) is expected to play an important role in diagnosis and as a sample collection method for CGP. At present, it seems essential to get sufficient tissue samples using a large-diameter fine-needle biopsy needle as much as possible. Further evidence needs to be accumulated for standardization of EUS-TA for CGP so that several patients can benefit from Precision Medicine.