2024 Volume 66 Issue 2 Pages 144-150
An 80-year-old female presented to our hospital with heartburn and hematemesis. Her current medications included minodronate for her osteoporosis. Esophagogastroduodenoscopy revealed circumferential ulceration with severe stenosis, that occluded the passage of an ultrathin endoscope in the lower esophagus. A thorough medical history was acquired, which revealed that she had taken her monthly minodronate tablet with a small volume of water five days prior to the onset of her symptoms. We suspected her esophageal lesion to be minodronate-induced esophagitis. On admission, she was advised fasting and treatment with vonoprazan was commenced. After three days, her symptoms resolved. Ten days post-admission the resolution of her esophagitis was confirmed via repeat endoscopy, and severe stenosis was no longer observed. We herein report a case of minodronate-induced esophagitis with severe stenosis that was revealed endoscopic improvement by observation following identification of the causal drug.
