2026 Volume 68 Issue 1 Pages 16-27
Pancreatic stones form as chronic pancreatitis progresses and can cause pain due to impaired pancreatic juice outflow. They may also complicate the clinical course by being associated with conditions such as pseudocysts and pancreatic fistulas. The diagnosis of pancreatic stones relies on various imaging modalities, including CT, MRI, and EUS. Symptomatic stones within the main pancreatic duct are considered indications for treatment. A multimodal therapeutic strategy that appropriately combines endoscopic procedures, extracorporeal shock wave lithotripsy, electrohydraulic or laser lithotripsy, and surgical interventions is required. After effective pain relief, follow-up is crucial for preventing recurrence and improving long-term outcomes. This includes assessing pancreatic function, screening for cancer using imaging techniques, and lifestyle modifications. Further evidence on the appropriate selection of treatment modalities and their long-term efficacy is required.