2026 Volume 68 Issue 9 Pages 1529-1535
A 67-year-old man underwent annual endoscopic surveillance for a subepithelial lesion in the greater curvature of the lower gastric body. After seven years, endoscopic ultrasound-guided fine-needle aspiration and boring biopsy were performed because of lesion enlargement and a newly observed apical depression; however, a definitive diagnosis could not be established. Local gastric resection confirmed the lesion as an adenocarcinoma. Additional distal gastrectomy was performed. A review of 26 cases of gastric cancer mimicking subepithelial lesions that were observed for ＞2 years revealed that many lesions enlarged over time with the development of central depression. Infiltration beyond the muscularis propria was observed in 11 patients, and lymph node metastasis was observed in four patients. Our findings suggest that early histological diagnosis and prompt lesion resection are important in cases of gastric cancer mimicking subepithelial lesions.
