Abstract
We applicated dye scattering method of methylene blue solution in 31 cases, indigocarmine one in 19 cases and Lugol's one in 124 cases, to the esophagoscopy for the description of fine uneveness of the esophageal epithelium and the supplemental endoscopic diagnosis of esophageal diseases. The obtained results were as follows; 1) By means of scattering the blue dye solution to the esophageal epithelium, we could clearly observed fine granular changes of esophageal epithelium in 16 cases (84.2%) among 19 scattered ones, and we could easily diagnose granular lesions, leucoplakia and II c type lesion of minute cancer with the aid of biopsy examination. Furthermore, this method clarified transparent blood vessels of submucosal layer through the epithelium in almost cases, esophagogastric junction in 7 cases and linear redness of epithelium in 5 cases. 2) We confirmed that Lugol's solution dyes the esophageal epithelium to brown and silk crape formed epithelium, from the results of animal experiments and microscopic investigation of frozen biopsy materials taken from the stained esophageal epithelium. 3) Whitisch granula and leucoplakia were dyed in black brown by this method, by which we could observe more clearly whitisch granula of the esophagus in 68 cases (74.7%) among 91 scattered ones than routine endoscopy. 4) Lugol's solution could not dye the cancerous lesion and esophagitis, but they could be more clearly observed in 27 cases (79.4%) among 34 scattered ones. 5) We could clearly observed the esophagogastric junction in 61 cases (62.9%) among 97 scattered ones of Lugol's solution. 6) From these results, we concluded that the dye scattering method for esophagoscopy is useful for supplemental diagnosis of esophageal diseases by reason of the clarification of minute depressed or elevated findings of esophageal epithelium.
