Abstract
The clinical significance of the gastric type epithelium surrounding mucosa of duodenal ulcers were studied endoscopically and histologically.Results:1) The gastric type epithelium in the duodenal mucosa showed the same features as the gastric surface epithelium histologically. The villi were indentif iable with redness and swelling under the endoscopic observation. It was considered that the gastric epithelium did not have any absorptive ability because it remained unstained in the methylen blue solution.2) From the studies of the resected specimens of the duodenal ulcers, the gastric type epithelium never occurred in the phase of active ulcers. But, as the healing of ulcer progress it appeared more often and also increased in severity.3) In 114 of 144 cases (79. 2%) of duodenal ulcers revealed the gastric typs epithelium at biopsy under the direct viewing endoscopy. Also it appeared more frequently as healing advanced. The gastric type epithelium appeared more increasingly in proportion to the patient's age and to the period of long history of the so-called difficult healing ulcers.4) The gastric type epithelium seemed to play a role of a defence factor and devaloped as metaplasia in the healing process of regeneration of ulcerative or erosive lesion in the duodenal mucosa.5) In the follow-up studies of the gastric type epitheliu-m by biopsy, it appeared more frequeatly among the cases undergoing remissions within 3 months. While the frequency did not increase in the cases with remissions requiring more than, 3 months. From these results, the follow up studies of the gastric type epithelium by biopsy are very effective in the evaluation of the prognosis of duodenal ulcers.
