1979 Volume 21 Issue 3 Pages 329-339
The authors measured disaccharidase (maltase, lactase) activity of gastric cancer (focus), intestinal metaplasia surrounding focus and intestinal metaplasia, 1.5cm-2.0cm distant from the focus, by gaschromatography and immunohistochemically studied by α-fetoprotein labeled with FITC. 1) Maltase and lactase activities showed no difference in part of early cancer and advanced cancer. 2) Maltase and lactase activities were higher in well differentiated cancer than poorly differentiated cancer. 3) As the distance from the focus was bigger, maltase and lactase activities become higher, and those of intestinal metaplasia in the stomach without gastric cancer showed the highest values. 4) Immunohistochemical localization of AFP in focus of poorly differentiated type was found in the cell membrane or cytoplasm. 5) We could find a positive APP or negative APP in intestinal metaplasia surrounding gastric cancer with AFP. 6) We could not find immunohistochemical localization of APP of intestinal metaplasis in the stomach without gastric cancer.
