1980 Volume 22 Issue 10 Pages 1395-1405_1
The authors measured disaccharidase (maltase, sucrase, lactase) activity of intestinal metaplasia, surrounding a gastric cancer, a gastric ulcer or a gastric polyp. Intestinal metaplasia at 1.5cm-2.0cm and 3.5cm-4.0cm distant from a focus was examined by gaschromatography, and immunohistochemical study of a-f etoprotein (AFP) labeled with FITC was also performed. 1) No difference of disaccharidase activities were shown in any part surrounding the gastric ulcer and gastric polyp. 2) As the distance from the focus was longer disaccharidase activities of intestinal metaplasia became higher, and those of intestinal metaplasia in the stomach without gastric cancer showed the highest values. 3) Immunohistochemical existence of AFP in gastric cancer was recognized in 20 of 41 cases (48.8%). 4) AFP was recognized in 66.7% of moderately differentiated adeno-carcinoma and 76% of signt ring cell carcinoma. While it was recognized in 37.5 % of poorly differentiated adeno-carcinoma and 33.3 % of well differentiated adeno-carcinoma. 5) Localization of APP was recognized at cytoplasm in poorly differentiated adeno-carcinoma and signet ring cell carcinoma. It was recognized at epithelium of gland and basal membrane in well differentiated adeno-carcinoma. 6) In the intestinal metaplasia surrounding a gastric cancer which contained APP, APP was recognized in 9 of 20 cases (45%). But APP not recognized in the metaplastic tissue surrounding a gastric cancer which had not APP.
