Abstract
One hundred eighty-three gastric protruded borderline atypical epithelial lesions in 170 cases were studied endoscopically and histopathologically. Furthermore, 82 lesions in 71 cases among them have been followed-up endoscopically and histopathologically during 6 months to 12 years with a mean interval of 6 months. The following results were obtained. 1) The gastric borderline aytpical epithelial lesions were found more frequently in the aged among gastroscopic examined patients: 0.1% in 3rd decade and 3.7% in 9th decade. The incidence of coexistent gastric cancers among the patients with these lesions was high-est in the 8th decade and was found more frequently in male patients with the ratio of 12 : 1. 2) Eight (9.80) of the 82 followed-up lesions showed changes in size, 4 (4.90) of which showed decrease in size and the other 4 (4.9%) increase in size.3) Twenty-one (25.6%) of the 82 lesions showed histological changes; 4 of 21 lesions (4.90) turned from group III to intestinal metaplasia, 8 lesions (9.8%) showed histolo-gical changes in cellular and glandular structures (from group III to IV, or viceversa), and 9 lesions (10.8%) were found to show malignant changes in follow-up study. 4) In relation between macroscopic changes and histological alterations, the more had the lesions increased in the histological atypism, the more were the lesions enlarged, and viceversa. However, there were 4 lesions (4.9%) which showed histological changes with-out alterations in size. 5) Cases which have a tendency to increase histological atypism as well as cases which show the gradual increase in size, are recommended to be subjected to polypectomy, piece-meal polypectomy, hot biopsy or surgical operation for more precise diagnostic accuracy and therapeutic purpose.
