A CASE OE DUBIN-JOHNSON SYNDROME ACCOMPANIED WITH CHRONIC HEPATITIS

Abstract

A case of Dubin-Johnson syndrome (D-Js) showing remarkable liver fibrosis was reported. The patient was 46 year old male with moderate hyperbilirubinemia and slight liver dysfunction. HBsAg, antiHBs and antiHBc were negative. BSP clearance showed moderate retardation and secondary rise, but ICG clearance was normal. In laparoscopic examination, the liver surface showed slight irregularity and decoloriza-tion to dark gray. Histology of the liver specimen showed remarkable fibrosis, chronic inflammatory cell infiltration, piecemeal necrosis and disappeared D-Js pigments particularly at the periportal area. From these findings, this D-Js case seems to be accompanied with non-B chronic active hepatitis.