A CASE REPORT OF A MALIGNANT ACANTHOSIS NIGRICANS ASSOCIATED WITH AN ESOPHAGEAL PAPILLONATOSIS AND A RENAL PELVIC CANCER.

Abstract

A 83 year old male was admitted with general fatigue and itching for a few months. Skin changes of verrcous protrusions were noted in the face, neck, hands, foot and body surface, as. well as hyperpigmentation in the perineum and mamillar regions. The lips, tongue and oral mucosa were also involved with papillomatosus thickening. Barium meal study showed numerous granular shadows throughout the esophageal surface. Endoscapi-cally, esophageal mucosa appeared thickened and finely granulated throughout the esophagus. These lesions were not found beyond the esophago-gastric mucosal junction. Endoscopical biopsy of the esophageal mucosa revealed squamous epithelial papillo matosis. Transitional cell carcinoma of the right renal pelvix was confirmed by retrograde pye-lography and a diagnosis for malignant acanthosis nigricans associated with renal pelvix cancer was established. The patient died of pulmonaly complication due to metastasis to the both lungs. Esophageal disorders such as diffuse granular protrusions seen in this old man is ex-tremely rare and shoud be differentiated from esophageal moniliasis, esophageal leukoplakia and a similar type of esophagitis.