INVESTIGATION OF EARLY STAGE OF INTESTINAL METANLASIA

Abstract

We investigated early stage of intestinal metaplasia by analysis of C-I type (Kimura, Takemoto classification) gastric mucosa. From its distribution, histology, enzyme activity (ALP, LAP), and autoradiographic study (H-thymidine), we clarified the pathophisiologic state of early stage of intestinal metaplasia. In many cases (88%), the distribution of early stage of intestinal metaplasia located only in the prepyloric region. And in some cased (12%) scattered in the antrum. From the histological and enzymological points of view, almost all cases are of an incomplete type of intestinal metaplasia (ALP-, LAP-), and all cases were short of the Paneth cell. According to the autoradiographic study (H-thymidine), we recognized enlargement of the generative cell zone and there was little difference between atrophic gastritis and early stage of intestinal metaplasia in labelling index (L. I.).