GASTROENTEROLOGICAL ENDOSCOPY
Online ISSN : 1884-5738
Print ISSN : 0387-1207
ISSN-L : 0387-1207
CHANGES OF THE MUCUS BARRIER DURING THE PROCESS OF DODENAL ULCER HEALING, IN SPECIAL
REFERENCE TO THE FINDINGS OF 3H-GLUCOSE AND 35SO4 AUTOLADIOGRAPHY
MUTSUO UECHIMASAHIKO TOMIMATSUYOKO MIWAKATASHI MATSUNOATSUSI MAEDAAKIRA AKAGAMIKATSUKO YAMASITAIZUMI YOKOYAMASHISHO ICHIOKAMASATAKA MARUYAMATADAYOSHI TAKEMOTO
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1981 Volume 23 Issue 4 Pages 514-520_1

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Abstract
The mucus secretion during the process of duodenal ulcer healing have been investigat-ed and the following results were obtained. It was found that the formation of the mucus barrier occured during the process of the ulcer healing at an earlier stage than that usually described. Already at the latter half of the active stage histochemical study by Alcianblue-PAS Staining, showed irregular PAS-positive staining in the surrounding part of the ulcer and the complete staining at the healing stage. In addition, autoradiography with 3H-glucose and 35SO4 revealed that these isotopes were incorporated mainly into the cells of the surrounding part or the mucus layer of the ulcer at the active stage, and the incorporations enhanced prominently at the healing stage. These results suggest that the formation of mucus barrier following mucus secretion initiates from the latter half of the active stage, at an earlier stage than that reported pre-viously. Importance of mucus barrier in the mechanism of the ulcer healing was suggested
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© Japan Gastroenterological Endoscopy Society
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