CHANGES OF THE MUCUS BARRIER DURING THE PROCESS OF DODENAL ULCER HEALING, IN SPECIAL

REFERENCE TO THE FINDINGS OF ³H-GLUCOSE AND ³⁵SO₄ AUTOLADIOGRAPHY

Abstract

The mucus secretion during the process of duodenal ulcer healing have been investigat-ed and the following results were obtained. It was found that the formation of the mucus barrier occured during the process of the ulcer healing at an earlier stage than that usually described. Already at the latter half of the active stage histochemical study by Alcianblue-PAS Staining, showed irregular PAS-positive staining in the surrounding part of the ulcer and the complete staining at the healing stage. In addition, autoradiography with ³H-glucose and ³⁵SO₄ revealed that these isotopes were incorporated mainly into the cells of the surrounding part or the mucus layer of the ulcer at the active stage, and the incorporations enhanced prominently at the healing stage. These results suggest that the formation of mucus barrier following mucus secretion initiates from the latter half of the active stage, at an earlier stage than that reported pre-viously. Importance of mucus barrier in the mechanism of the ulcer healing was suggested