Abstract
A 75 years old man was admitted to Nagoya University Hospital with chief complaints of anorexia and soft stool in April 1978, when hyperpigmentation of the extremities and deformity of finger nails were observed. The laboratory examination revealed hypoprotein-emia, electrolyte-inbalance and elevated plasma protein loss rate (RISA). Roentgenographic and endoscopic examinations revealed diffuse polyposis in all parts of GI tract except for esophagus Histologically, colonic polyp showed a cystic dilatation of glands and edema-tous stroma with slight cell infiltration. Soon after admission, clinical symptoms were improved by administration of predoni-solon, so the patient was followed-up with maintenance dose of predonisolon. GI tract ex-amination performed 18 months later revealed remarkable decrease of the number of poly-posis in both stomach and colon. Recently, the number of reported cases of Cronkhite-Canada syndrome has been increas-ing, but there has been relatively few cases which are characterized by decrease of the num-ber of GI tract polyposis. However the etiology of this syndrome is unknown, this case has given us some suggestions about etiology of GI tract polyposis in this syndrome.
