Abstract
To clarify the binding of sucralfate in gastric ulcer and gastritis, the author observed endoscopical and histochemical distribution of sucralf ate using gastroscopy or biopsy specimen and assayed sucrose sulfate ester and aluminum in biopsy specimen obtained from ulcer or nonulcer areas in 47 patients with peptic ulcer and in gastric mucosa associated with gastritis obtained from nonulcer areas in 10 patients who were operated on for recurred or unhealed ulcer. With regard to gastric ulcer, sucralfate was selectively found in the lesions (Table 1. 2, Figure 1-1, Figure 2-B), and sucrose sulfate ester and aluminum were detected in the lesions (Table 4, Figure 3). In chronic gastritis, there were no correlation between histological changes and the binding of sucralfate (Figure 6), though in gastric superficial imflammatory reactions a significant correlation could be demonstrated between sucrose sulfate ester and adhesive mucus or congetion (Figure 7).
