MUCOPOLYSACCHARIDE IN HEALING PROCESS OF GASTRIC ULCER WITH SPECIAL REFERENCE TO ³⁵SO₄ AUTORADIOGRAPHIC FINDINGS AND AMOUNT OF HEXOSAMINE WITHIN MUCOUS MEMBRANE

Abstract

This study presents protective mechanism of the mucous membrane with our main emphasis on mucopolysaccharides within the mucous membrane at varying stages of gastric ulcer. If we look at the findings based on ³⁵SO₄ autoradiography, an increase in uptake of ³⁵SO₄ by the epithelial cells of the active stage (A₂) and a peak is exhibited during the initial half of the healing stage (H₁). If the amount of hexosamine within the mucous membrane is determined, a movement similar to the ³⁵SO₄ autoradiographic findings is exhibited with a peak occourring from the A₂ to the H₁ stage. In summary, it is conceivable that based on the mucopolysaccharide metabolism during the varying stages of gastric ulcer, formation of a mucous barrier is quite rapidly initiated after ulceration and the importance of a protective facter in healing process of gastric ulcer is suggested.