Abstract
Forty-four early gastric cancer cases with gastric ulcer or ulcerscar at the different site (accompanying group) were studied, compared with 223 cases of early gastric cancer without gastric ulcer (control group). Results obtained were as follows ; 1) Peptic ulcer was discernible at the different site of the stomach from the cancerous lesion in 44 (16.5%) of 267 early gastric cancer cases. 2) Mean age of the accompanying group was 56.4±8.3 years of age, while 54.8±12. 7 years of age in the control group. Male/Female ratio was 6.3 in the former, while 2.6 in the latter. 3) Depressed type of early gastric cancer, especially IIc + III type, was dominant in both groups. 4) Concerned with the depth invasion of cancer, mucosal cancer was more freguently found in the accompanying group, and the size of early gastric cancer was also smaller in this group, with a statistical difference to the control group. 5) Histologically, differentiated type of adenocarcinoma was dominant in both groups. 6) With respect to the relationship between early gastric cancer and peptic ulcer in the accompanying group, early cancer was generally located at the anal site from peptic ulcer. In 19 cases, a combination of early gastric cancer at the antrum and peptic ulcer at the angulus was observed. 7) According to CMA classification, early gastric cancer was located in the “A” area in the accompanying group in general, while in the “M” area in the control one. However, the distribution of the surrounding mucosa of early cancer was not different in both groups. 8) The degree of intestinal metaplasia around early gastric cancer was significantly more remarkable in the control group. 9) Maximum acid output by tetragastrin (4r/kg body weight) showed hyperacidity in the accompanying group, especially in the cases with active stage of ulcer.
