Abstract
The experimental chronic pancreatitis model was successfully made by using the contact freezing method. By using this model, we studied the correlation between the histological findings and pancreatogram, especially about the adjacent fibrosis and stricture of the main pancreatic duct. The results were as follows; 1) Fibrosis was shown surrounding the main pancreatic duct at the contact freezing point. 2) Histologic section of the main pancreatic duct was deformed by the its surrounding fibrosis. 3) The inner diameter of the main pancreatic duct at the freezing point was decreased in the case with periductal fibrosis. 4) The distal main pancreatic duct was dilatated and the surrounding tissue was histologically alterated. According to these results, we had the opinion that the deformation and stricture of the main pancreatic duct due to adjacent fibrosis were the manifestation of early stage of the chronic pancreatitis.
