Abstract
It has been known that, unlike usual gastrointestinal malignancies, carcinoid tumor is one of the functional or hormone-producing tumor. In this paper, we presented a case of carcinoid tumor of the stomach, associated with primary biliary cirrhosis. The patient, a woman 56 years of age, visited our hospital in 1977 complaining of nausea. X-ray pictures revealed the protruded lesion, measuring 2.3 × 1.8 cm, at the anterior body of the stomach. Endoscopic examination revealed the protruded Yamada's type III lesion at the anterior body and the small protruded lesions at the lesser curvature and posterior wall. By endoscopic polypectomy in 1980, it was diagnosed carcinoid tumor, and she was operated on. In histological finding of polypectomized specimen, the neoplastic cells showed medular, trabecular, and glandular patterns. In resected stomach, four small carcinoids formed trabecular pattern and non-argentaffin, argyrophil cells were shown by silver impregnation by Grimelius method. The levels of gastrin and histamine were high in blood and normalized after operation. By wedge biopsy of the liver at operation, serial sections revealed bile duct destruction with periductal cellular reaction, and it was diagnosed primary biliary cirrhosis.
