Abstract
The therapeutic effect of cimetidine, and prophylactic effect of cimetidine and vagotomy on the post-operative stress ulcers were evaluated. 1) Bleeding stopped in 19(58%) of 33 patients with cimetidine-treatment, and in 8(29%) of 28 with conventional antacid-treatment. Cimetidine controlled successfully massive bleeding from stress ulcer, but had no significant improvement for mortality . Particularly in hepatoma with cirrhosis, we had only poor results of conservative treatment of stress ulcers following surgery. 2) Prophylactic cimetidine-treatment and vagotomy to gastric hypersecretors of hepatoma with cirrhosis prevented effectively post-operative gastoduodenal bleeding caused by stress ulcer. Prophylactic treatment may be the most beneficial approach to decrease the mortality of post-operative stress ulcer .
