A CASE OF BENIGN RECURRENT INTRAHEPATIC CHOLESTASIS OCCURED AFTER DELIVERY

Abstract

Benign recurrent intrahepatic cholestasis is a very rare form of jaundice. We report here a case of benign recurrent intrahepatic cholestasis occured after delivery. A 25 year old female who had four episodes of jaundice was admitted because of recurrence of jaundice two weeks after her first delivery. On laparoscopy, liver had smooth surface, sharp edge and greenish-brown color. Histological findings showed the accumulation of bile pigment in the bile canaliculi particulary in the centrilobular region.There was no evidence of inflammation or fibrosis. Electron microscopy revealed dilated bile canaliculi filled with electron-dense deposits and thickend pericanalicular zone. There was marked loss of canalicular microvilli. Although serum Al-P level was elevated, serum γ-GTP level stayed within normal range during period of jaundice. It is suggested that the attack of benign recurrent intrahepatic cholestasis of this case occured in response to delivery.