LIVER FIBROSIS IN FATTY LIVER

Abstract

Forty eight cases of the fatty liver in obesity were classified into three groups according to the grade of fatty changes and were investigated about liver fibrosis. Peritoneoscopic findings of the liver surface of fatty liver shows characteristically almost smooth and diffuse yellowish brown surface or cobblestone-like yellowish markings. Moreover, we often observed small depressions and dilatation of small portal vessels on the liver surface. In this study small depressions were seen in 17 cases (35.4%) and dilatation of small portal vessels were seen in 9 cases (18.8%). These findings were observed in severe fatty liver more frequently than mild and slight fatty liver, ; Histological findings of the liver biopsy specimen in severe fatty liver showed frequently hepatic cell necrosis and fibrosis around the central veins. In severe fatty liver the incidence of PP bridging fibrosis was 25% and the incidence of P-C bridging fibrosis was 30%. However, we did not experience that fatty liver showed lobular distortion all over the liver. Our findings suggest that the sinusoidal block according to fatty cysts caused hepatic cell necrosis and fibrosis around the central veins when the fatty liver in obesity became severe.