1984 Volume 26 Issue 9 Pages 1481-1488_1
We have experienced 7 cases of giant ulcer showing the protruding change of the ulcer floor on its healing process. These gastric ulcers were treated with histamine H2 receptor antagonist, e. g. Cimeditine, Ranitidine and Famotidine. Location of the lesion was the angulus in one case and the body in 6 cases. Compared with the group treated with conventional anti-ulcerative drugs, the period from active stage to healing stage was short in this group. The protruded change of ulcer floor appeared 5-6 weeks after the treatment and healed as a red scar 4-10 weeks later. Biopsy specimen from the protruded lesion showed granulation tissue which consisted of cell infiltration and renewed capillary without regenerated epithelia. There has been only one resected case treated with histamine H2 receptor antagonist so far in Japan. Histopathological examination proved that this lesion consisted of the same fresh granulation tissue with slight regenerated epithelia and marked fibrosis beneath it. It was suggested that the lesion would develop due to unbalanced rapid repairment of ulcer floor and edge.
