1984 Volume 26 Issue 9 Pages 1538-1542_1
A 42-year-old man visited our hospital with a complaint of epigastric discomfort. Fluoroscopic examination of the stomach revealed multitudinous barium flecks of differentsizes spreading from the lower body to the antrum. Endoscopic methylene blue (MB)staining method of the stomach revealed zonal intestinal metaplasia of depressed type spreading along the fundic-pyloric mucosal border over the anterior and posterior walls with its depressed region found in the fundic gland area. An 8-year observation with the MB staining method showed that intestinal metaplasia of depressed type changed partly to that of flat type and spread proximally. During the period of observation, intestinal metaplasia newly developed in the antral and cardic regions, and the antral intestinal metaplasia also spread upwards and the cardiac intestinal metaplasia spread downwards. Follow-up observation in this case revealed developing directions of intestinal metaplasia of the stomach..
