Abstract
A 37 year-old male was admitted to Akita University Hospital because of dysphagia and weight loss. An uppergastrointestinal series showed a funnel-shaped esophagus with irregular margin and the rigidity of the lesser curvature of the gastric body. Endoscopic examination disclosed a circular stenosis with irregular surface at 30 cm distal from incisor. However, GIF-P3 could be inserted into the stomach. Circumscribed mass at the cardia and multiple erosions in the gastric fundus and body were seen. Biopsy specimens from esophageal and gastric mucosa showed the signet cell carcinoma. Lower esophagectomy and total gastrectomy with Roux en Y anastomosis were performed. Histologically, signet cell carcinoma with marked hyperplasia of intestinal connective tissue were found from thoracic esophagus to gastric antrum. Carcinomatous infiltration in all layer of the esophagus was observed.
