Abstract
A 74-year-old male, who was a father case, was admitted to our hospital because of hematemesis. Upper GI series and endoscopic examination showed a solitary polyp 15mm in diameter on the anterior wall of the duodenal bulb . His son was a 43-year-old male complaining of epigastric pain. Upper GI series and endoscopic examination showed multiple small elevated lesions in the duodenal bulb. In both cases, the target biopsy by endoscopy was demonstrated true gastric fundic mucosa, and a diagnosis of heterotopic gastric mucosa in the duodenum was established. They are the first familial cases of heterotopic gastric mucosa in the duodenum detected by radiologic and endoscopic exami nation.