Abstract
Experimental studies were performed in order to make sure pathogenesis of the Mallory-Weiss syndrome. 1) The prolapse of the gastric mucosa into the esophagus was observed by endoscopic cinefilm at the anterior wall near the greater curvature as the morphological change at the cardia due to retching or vomiting. 2) The intragastric pressure caused by retching or vomiting was from 170 to 290 cm H2O (an average of 231 Cm H2O). 3) The tears were produced in 10 anesthetized dogs due to distending the stomach with air. The intragastric pressures required to produce the tear were from 190 to 210 Cm H2O (an average of 200 Cm H2O), the pressures of perforation were from 190 to 270 Cm H2O (an average of 232 Cm H2O). These longitudinal mucosal tears were observed at the cardia and on the lesser curvature, and they were amazingly similar to the Mallory-Weiss tear in human. In conclusion, the location of the tears may be regulated by anatomical and histological factors.
