Abstract
In order to make a correct assessment of gastric secretion and to evaluate the defensive and aggressive factors of stomach in peptic ulcer diseases, we performed an endoscopic gastric analysis by the pan-endoscope. Gastric juice was collected every 10 minutes, before and after the stimulation of tetragastrin (4μg/kg). The endoscopic gastric analysis was performed in 49 subjects, 19 cases of gastric ulcer, 14 cases of duodenal ulcer, 8 cases of gastro-duodenal ulcer and 8 cases of hospital control. By six biopsy specimens simultaneously obtained, the atrophic border was decided, and classified into C1, C2, O1 and O2. Macromolecular glycoproteins (Fr. I hexose) in both the collected gastric juice and biopsy specimen from the antral mucosa were extracted, fractionated on Bio-Gel A-1.5m column chromatography, and analysed by the phenol sulfuric acid method. BAO decreased in the order of C1, C2, O1 and O2. There was a linear correlation between BAC and the concentration of Fr. I hexose in basal secretion (r=-0.609, p<0.01). Fr. I hexose of biopsy specimen in gastric ulcer patients was 7.8±0.6μg/mg and 10.9±0.8μg/mg in duodenal ulcer patients. There was a significant difference (p<0.01) between them. We also found a linear correlation between BPO and Fr. I hexose in biopsy specimen (r=0.443, p<0.01). Thus, we can perform the study of gastric function including defensive and aggressive factors by the endoscopic gastric analysis, as well as simultaneous morphological examination of the stomach.
