GASTRIC MOTILITY AND COMPLAINTS IN PATIENTS WITH FUNDAL GASTRITIS

Abstract

Gastric emptying and gastric peristalsis in 31 patients with and without fundal gastritis were measured by the acetaminophen absorption method and endoscopic procedures, respectively. The relation of gastrointestinal and related complaints to the extent of fundal gastritis and gastric motility was investigated. The extent of fundal gastritis was estimated by the endoscopic Congo red test. In patients with severe fundal gastritis, gastric emptying was significantly delayed, and gastric peristalsis was also significantly slower than in patients without severe fundal gastritis. Gastrointestinal and related complaints, especially epigastric fullness and f atigability were more frequent in patients with delayed gastric emptying. The acute effect of oral administration of domperidone on gastric emptying and gastric peristalsis was assessed. A single administration of domperidone (20 mg) significantly increased the rate of gastric emptying and accelerated gastric peristalsis.