1986 Volume 28 Issue 3 Pages 531-541
To delineate the characteristic findings of the mucosal lesions of antibiotic-associated colitis, endoscopic observation has been done in 49 cases which have been admitted in our hospital during these 7 years. Antibiotic-associated colitis in these cases were classified into 4 types accoring to the endoscopic findings of the lesion: 18 cases with pseudomembranous colitis (PMC), 15 cases with acute hemorrhagic colitis (AHC), 13 cases with aphthoid colitis (APC), and 3 cases with unclassified lesion. In 28 case out of 49 cases, dye spraying method and endoscopic magnifying observation have been done. Main mucosal findings of AHC were mucosal hemorrhage and edema, which generally disappeared within about one week. Varioliformed protrusions in cases with APC decreased gradually in the size and height, and finally left only shallow depressions about one month later. Lymphfollicular proliferation was confirmed by biopsy in the submucosa of each variolif ormed protrusion. In 10 out of 11 cases with PMC followed-up endoscopically, pseudomembranous lesions were disappeared within 2 weeks, remaining varioliformed or punctif ormed erosions during 2 to 3 months. By magnifying observations of the regenerative mucosa of lesions in 28 cases, irregularity and disordered arrangement of the pits were observed on the mucosa only in the case with PMC, whereas no irregularity or disarrangement of the pits were seen on the mucosa in cases with AHC and APC. From these results., it can be said that each mucosal lesion of PMC, AHC and APC shows each characteristical healing process.
