1986 Volume 28 Issue 3 Pages 632-641
A family of the cancer family syndrome containing six cases of colorectal cancer and a case of endometrial cancer was reported. The proband, 44 years old female with cancers in the ascending colon and multiple colon polyps, received right hemicolectomy for the former and endoscopic polypectomy for the latter. These were confirmed to be five synchronous multiple colon cancers. Multiple polyps developed in the residual bowel in a rather short period after the operation. Her grandfather had a large bowel cancer and her father had a metachronous multiple cancers of the large bowel and a ureteral cancer. Her two aunts had a colorectal cancer and the other aunt had an endometrial cancer. Her young brother also had a colorectal cancer. Six out of eleven colorectal cancers among these cases were in the right colon and the remainder was in the left colon. Colorectal cancer developed evidently at earlier ages in these cases compared to those seen in conventional colorectal cancer and the later the generation became, the earlier the age of the onset became. Therefore, a careful designed screening program for off springs of the cancer family syndrome is mandatory.
