ENDOSCOPIC LOCAL INJECTION OF AETHOXYSCLEROL TO UPPER GASTROINTESTINAL BLEEDING

Abstract

Several endoscopic methods have been applied to the upper gastrointestinal bleeding. The present report describes a new method, using Aethoxysclerol, of treating upper gastrointestinal hemorrhage endoscopically. Aethoxysclerol commonly used as sclerosant of sclerotherapy, was applied to arrest hemorrhage from the upper gastrointestinal tract. At first fundamental effect of local injection of Aethoxysclerol solution was evaluated using the dog. It was recognized that effect of injection was due to compression of vessels by edema of stroma and microthrombosis and late effect was due to formation of thrombo-sis by endvasculitis. In clinical use, Aethoxyscleral was injected circumferentially to a total of 3-4 ml beneath the base of bleeding lesions. In 13 of 15 cases, this procedure had a definite benefit for the patient and no complication occured. It was concluded that local injection of Aethoxysclerol was safe and an effective method for the hemostasis of upper gastrointestinal bleeding.