1986 Volume 28 Issue 6 Pages 1304-1308_1
Familial incidences of Crohn's disease (CD) reported in Europe and USA are about 10%, but there are only two case reports in Japan. In our hospital, in two families of 67 unrelated patients with CD, a first-degree relatives with CD was found. In this paper, we report a mother-son case. The mother is 48 years old. She had dairrheas in 1975, and slight fever in 1977. She had pains in the periumbilical and ileocaecal region and the anus in 1980. In September 1983, she had a ileocaecal pain again. Her condition became worse from December 1983. She was admitted to our hospital on April 1984. Barium enema, small bowel enema and colonoscopic examination revealed cobblestone appearances and longitudinal ulcers. Furthermore, granulomas were found in biopsy specimens. Her second son is 18 years old. Epigastric hunger pains began in march 1984. He had aphthoid stomatitis and complained of watery stools in September. X-ray and endoscopic examinations revealed duodenal ulcers, a longitudinal ulcer and cobblestone appearance in the terminal ileum and aphthoid ulcers in the sigmoid colon. We found granulomas in all biopsy specimens from the margin of the duodenal ulcer, the terminal ileum and the colon. We analized HLA antigens in this family. The mother had BW 61 and DR4, which have been reported more frequent in Japanese patients with CD, and her son had BW61.
