THE SAFETY AND THE MECHANISM OF ACTION OF ETHANOLAMINE OLEATE USED IN INJECTION SCLEROTHERAPY

Abstract

The safety and the mechanism of action of 5% etanolamine oleate (EO) used in endoscopic injection sclerotherapy (IS) were studied. Thirty-six canine models, 47 canine cephalic veins, clotting parameters of 17 human cases before and after IS, and 9 human autopsy cases after IS were used in this study. The following results were obtained.1. EO is a safe sclerosant if it is injected into esophageal varces with total amount of less than 0.5 ml/kg in a single IS.2. Thrombus that obliterates vein occured not immediately, but within 1-6 hours after intravenous injection, and intravenous injection was more effective than perivenous one.3. Damage of venous endothelium was the first histological change after intravenous injection of EO, and this change should be evaluated as the most important role of EO.4. In one autopsy case died 6 days after IS, "bronze varices" which is proved to be the varices obliterated by thrombus was recognized.5. Clotting parameters were examined before and 24 hours after IS. But, no influences were noted on coaglation system.