1986 Volume 28 Issue 7 Pages 1605-1609_1
Four cases of Wilson's disease including three asymptomatic cases were reported with special reference to peritoneoscopic findings. Two of three asymptomatic patients happened to be found because of the elevation of serum alkaline phosphatase. In all cases, hypocupremia and hypoceruloplasminemia were present and urinary copper excretion was increased. Peritoneoscopy showed yellowish or dark smooth liver in asymptomatic patients. That of symptomatic case showed mixed nodular post-necrotic liver cirrhosis with yellowish degenerative nodules. Histological findings showed nuclear vacuolation and fatty degeneration of hepatocytes. In the cirrhotic case the regenerative nodules were surrounded by wide fibrous stroma. Rhodanine stain was negative in one case. There was a discrepancy between liver copper levels and Rhodanine stain of the liver tissue.
