CLINICAL AND ENDOSCOPIC STUDY ON RECURRENCE OF GASTRIC AND DUODENAL ULCER MAINTENANCE TREATMENT

Abstract

Among the subjects of gastric ulcer (106 cases) and duodenal ulcer (69 cases), analysis was made on the alteration or time course of endoscopic findings and relapse under maintenance therapy for one year. Also, histological review of the biopsy has been made. As a result, endoscopic cumulative recurrence rate (one year) was 57.5% with gastric ulcer and 60.9% with duodenal ulcer. Whereas, about 70% of relapsed cases showed asymptomatic recurrence, and also, the group of asymptomatic recurrence showed clearly smaller and shallower ulcer than in symptomatic group, thus it was considered to be the effect of maintenance therapy. In the analysis of the background, the relapse of gastric ulcer was greatly affected by compliance, cigaret habit and size of ulcer. The relapse of duodenal ulcer was also greatly affected by the history of ulcer and compliance. In the analysis of endoscopic findings, all the relapsed gastric ulcer was due to the occurrence of red scar. However, the transfer rate to white scar from red scar in non-relapse cases in one year was 51.1%. In comparison to the ulcer in the usual healing process, the ulcer showing protruded healing process in the cases to which histamine H2 receptor antagonist were given, is definitly greater in size at the start of treatment. However, there was no difference in the relapse rate, therefore it is difficult to estimate the relapse by endoscopic pictures.