Abstract
Follow up study was made in 195 patients either with or without H2 receptor antagonists in maintenance dose after their ulcer healed, group I medication with full maintenance dose, group II : intermittent and group III : discontinued medication. In patients with PGI < 68ng/ml (50 patients, 25.8%), there was no statistical significance in three groups classified by medication. In patients with 68ng/ml≤ PGI <95 ng/ml (63 patients, 32.1%), 13.3% of group I, 45.2% of group II and 29.4% of group III showed recurrence, which was statistically significant between group I and II (p <0.05). In patients with 95 ng/ml≤ PGI < 141 ng/ml (53 patients, 27.2%), 33.3% group I, 80.8% of group II and 73.3% of group III showed recurrence, which was statistically significant in three groups (p <0.01 : between group I and II, p <0.05 : between group I and III). In patients with PGI 141 ng/ml (29 patients, 14.9%), all of group II and III, and 66.7% of group I showed recurrence. There was no statistical significance in three groups. It was concluded from this study PGI is useful for the determining maintenance dosages.
