1987 Volume 29 Issue 11 Pages 2456-2465
The artificial gastric ulcers which are produced endoscopically by strip biopsy are UL-II in depth, and their healing process is thought to be a model of clinical acute gastric ulcers. In clinical and experimental (canine) studies, I week after ulcer formation, regener-ation epithelium maybe observed with dissecting microscope and magnifying endoscope. At the same time, the proliferative zone is enlarged at the ulcer's edge. After 2 weeks, the regeneration epithelium grows to a palisade-like appearance on endoscopical observation, and generative cells can be detected in the regeneration epithelium with the bromodeoxyur-idine (BrdUrd) labeling method. Using a laser measurement endoscope it was observed that the area of canine artificial gastric ulcers is uniformly reduced. In clinical cases, all artificial ulcers healed within 6 weeks. The 4-week cumulative healing rate is 50% in the non-H2 blocker group, 68.8% in the H2 blocker group and 75.5% in the combined group. It is suspected that a state of decreased acid secretion is also good for mucosal regeneration in normal stomach. In conclusion, moderate scaled UL-II clinical acute gastric ulcers are thought to heal within 6 weeks under ordinary anti-ulcer drug therapy.
