1987 Volume 29 Issue 11 Pages 2539-2545
A 58-year-old man with clinical features of Cronkhite-Canada syndrome is reported. He was admitted to Shimada-city Hospital complaining anorexia, diarrhea and edema. Multiple polypoid lesions in the stomach, the duodenum and the colon were seen on endoscopy and skin pigmentation, alopecia and onychodystrophy were found on physical examination on admission. The symptoms and signs were improved in three months with hyperalimentation and administration of 40 mg of prednisolone per day. In a serial colonoscopic obserbation, however, three polyps remained in the sigmoid colon. The biopsy specimen of the largest one (17 mm in diameter) showed adenocarcinoma. Subsequently, sigmoidectomy was performed at a surgical department in our hospital. The adenocarcinoma invaded into the proper muscle layer with local lymphatic metastases histologically.
