HEALING PROCESS OF ARTIFICIAL ULCERS PRODUCED BY STRIP BIOPSY (2) EXPERIMENTAL STUDY IN THE DUODENUM

Abstract

The artificial duodenal ulcers which are produced endoscopically by strip biopsy are UL-II in depth, and their healing process may be thought of as a model of clinical acute duodenal ulcers. In experimental (canine) studies, 1 week after ulcer formation in non-Brunner's gland area, regeneration epithelium may be observed as comb like shape under dissecting microscope. And at the same time, the regeneration epithelium has no generative cell. After 3 weeks, the regenerative epithelium grows to tear drop shaped regeneration villi, and many generative cells can be detected in the cryptoid portion with the bromodeoxyuridine (BrdUrd) labeling method. But in Brunner's gland area, 1 week after ulcer formation, Brunner's gland situated under the ulcer floor, changed its acini flattend, got many generative cells and already produced regeneration epithelium. In conclusion, Brunner's gland play a very important role in duodenal ulcer healing.