GASTROENTEROLOGICAL ENDOSCOPY
Online ISSN : 1884-5738
Print ISSN : 0387-1207
ISSN-L : 0387-1207
HEALING PROCESS OF ARTIFICIAL ULCERS PRODUCED BY STRIP BIOPSY (2) EXPERIMENTAL STUDY IN THE DUODENUM
Hideo YANAIMasahiro TADAMikio KARITANobuhiko HAYASHITakahiro YAMASAKIKazuko HIROTAKazuya MATSUDAShinji OKAHirohumi KAWANOMasaki SHIGEEDATakahumi KOUCHIYAMAYukinori OKAZAKITadayoshi TAKEMOTO
Author information
JOURNAL FREE ACCESS

1987 Volume 29 Issue 12 Pages 3036-3045

Details
Abstract
The artificial duodenal ulcers which are produced endoscopically by strip biopsy are UL-II in depth, and their healing process may be thought of as a model of clinical acute duodenal ulcers. In experimental (canine) studies, 1 week after ulcer formation in non-Brunner's gland area, regeneration epithelium may be observed as comb like shape under dissecting microscope. And at the same time, the regeneration epithelium has no generative cell. After 3 weeks, the regenerative epithelium grows to tear drop shaped regeneration villi, and many generative cells can be detected in the cryptoid portion with the bromodeoxyuridine (BrdUrd) labeling method. But in Brunner's gland area, 1 week after ulcer formation, Brunner's gland situated under the ulcer floor, changed its acini flattend, got many generative cells and already produced regeneration epithelium. In conclusion, Brunner's gland play a very important role in duodenal ulcer healing.
Content from these authors
© Japan Gastroenterological Endoscopy Society
Previous article Next article
feedback
Top