A CASE OF GASTRIC ULCER ASSOCIATED WITH MARKED PROTRUSION OF ULCER FLOOR IN THE COURSE OF CIMETIDINE TREATMENT

Abstract

The 68-year-old woman visited our clinic in October 1984 with a complaint of epigastric pain. The first X-ray and endoscopic examination in our clinic revealed an ulcer in active stage with ordinary appearance on the posterior wall of middle corpus. Healing tendency was poor in spite of the cimetidine (800mg per day) treatment, and moreover follow-up study with endoscope showed progressive protrusion of the ulcer floor. Finally, it grew into a early gastric cancer-like elevated lesion, gastric resection was performed accordingly in April 1985. Histological study of resected specimen showed no malignancy and the prominent protrusion was considered mainly due to marked fibrosis of the submucosal layer.