Abstract
Nineteen patients undergoing hemodialysis with chronic renal failure (CRF group) and 16 patients without renal diseases (Control) were studied. The average age was 44.4 years for CRF group and 46.3 years for the control, while the duration of hemodialysis ranged from 1 month to 12 years (averaging 5.8 years). Investigation included serum gastrin assay and f iberscopic gastroduodenoendoscopy with stepwise biopsies. The biopsies were done along the lesser curvature at five points-the duodenum, antrum, angulus, lower body and upper body. We have obtained the following findings : 1. Fiberscopic studies-Erythema or hemorrhagic gastritis was present in 47.8% in CRF group, compared with 18.8% hn the control. 2. Histological studies-Of the biopsied parts, the most conspicuous differences between the 2 groups were noted at the gastric angulus, the fundic gland mucosa being observed in 62.2% in CRF group, compared with 14.3% (p<0.01) in the control. No significant correlation was observed between the frequency of the fundic gland mucosa in the angulus and the duration of dialysis, nor the serum gastrin concentration in CRF group, but the frequency was reduced in cases over 45 years of age compared with the younger generations. 3. These suggest that the border line between the fundic gland mucosa and the antral gland mucosa exists closer to the antral side in CRF group compared with the control.
