Abstract
The effect of famotidine on gastric mucosal blood flow (GMBF), transmucosal potential difference (GMPD) and mucosal pH (GMpH) were studied by endoscopy in five healthy subjects. And the effects on serum gastrin and secretin were also investigated. Before administration of 20 mg/hr of famotidine, GMBF of the antrum, angle and body was 53.9 ± 8.5 (M ± SE), 57.7 ± 10.9 and 64.2 ± 12.1 ml/min/ 100 g respectively. After the administration, the GM BF was 95.1±10.5, 108.1±11.2 and 80.4±11.7 ml/min/100g respectively. After the administration of famotidine GMBF was significantly increased in the three regions. GMPD was also significantly increased especially in the body. But there were no significant changes on serum gastrin and secretin levels. From these results, it was suggested that famotidine enhanced the gastric mucosal resistance in addition to the inhibition of acid secretion.
