Abstract
This case report describes two patients of multiple lymphomatous polyposis (MLP). The first case was 73-year-old male who was admitted because of intractable diarrhea. X-ray and endoscopic examination of the GI tract revealed innumerable polypoid lesions in the stomach, small intestine, descending colon, sigmoid colon and rectum. The second case was 72-year-old male who was admitted because of epigastralgia. X-ray and endoscopic examination showed giant folds, a submucosal tumor of the stomach and innumerable polypoid lesions extending from the small intestine to the transverse colon. Biopsy specimens of the two cases revealed diffuse lymphoma, medium cell type. After chemotherapy (VEMP), the X-ray and endoscopic findings were markedly improved. Twelve cases of MLP in Japan were reviewed and their prognoses were reported to be better than those of primary gastric, small intestinal-or colorectal malignant lymphoma.