AN ELEVATED LESION ON ULCER BASE IN PATIENTS TREATED WITH H₂-BLOCKERELEVATED LESION

DIFFERENCES IN ELEVATED TYPE OF GASTRIC ULCER SCAR AND WHITE

Abstract

An elevated type of gastric ulcer scars(EUS) in 8 patients treated with H₂-Blocker (A) were compared with that in 15 patients EUS, not treated with H₂-blocker (B). Moreover, a white elevated lesion (WEL) seen in 7 patients was compared with EUS and the difference was discussed. The incidence of EUS and the mean age of the patients were higher in A than B. EUS was seen throughout the stomach in A, and only in the antrum in B. EUS was an elevation with regenerated tissues and the histological appearance showed f oveolar hyperplasia. The period from detection of gastric ulcer to confirmation of EUS averaged 4 weeks. However, EUS still remains several months later. On the other hand, WEL was an elevation with white colour and the histological appearance showed granulation tissues. The period from detection of gastric ulcer to confirmation of WEL averaged 4 weeks, and several weeks later, WEL disappeared. Therefore, these elevated lesions have some differences in findings of endoscopy, histology and follow-up study. It seems that EUS and WEL were induced by rapid tissue regeneration due to the strong anti-ulcer effect of H₂-blocker on an ulcerated area.