1988 Volume 30 Issue 11 Pages 2652-2656_1
We report here a 35-years-old female who developed primary biliary cirrhosis (PBC) following her third delivery. The patient had been quite healthy until her third pregnancy, during which she started to feel the itch sensation. Jaundice appeared one month after the delivery, and the patient was admitted to a hospital. The laboratory data there revealed a marked elevation of serum bilirubin, Al-p, Ig-M and a moderate increase in transaminase. In addition, antimitochondrial antibody showed positive. Based upon there laboratry findings, the patient was suspected as having PBC. For further examination and treatment, she was transferred to our hospital. Subsequent histological examination performed under a peirtoneoscopy revealed the presence of chronic non-suppurative destructive cholangitis, a characteristic finding of PBC, confirming the diagnosis. The case was classified as the stage II (Sheuer). The elevated levels in the above-mentioned liver function tests signifi-cantly decreased along a course of time without any specific treatment, although pruritus persisted. It was suggested that the hormonal changes caused by pregnancy and delivery might be involved in the development of PBC in this case.
