Abstract
Successful antibiotic therapy for pancreatic infection requires tissue penetration. The penetrance of several antimicrobial agents into the pancreatic juice was assessed by comparing antimicrobial concentrations between pure pancreatic juice at the time of endoscopic retrograde pancreatography and serum. The estimated antimicrobial agents were Ampicillin, Mezocillin, Cephamandol, Gentamicin, Amikacin, Clindamycin, Chloram-phenicol, Metronidazole and Trimethoprim-sulfamethoxadole. Good penetrance into the pancreatic juice was recognized only in Chloramphenicol, Metronidazole and Trimetho-prim. The intrapancreatic ductal levels of Ampicillin, Mezocillin, Cephamandol, Gentamycin, Amikacin and Clindamycin were very low, and we conclude the penetrance of these antimicrobials to the pancreas is very poor.
